205 citations · 229 across the 8 of their papers we have counts for
8 papers
Theoretical and computational tools to model multistable gene regulatory networks
Federico Bocci, Dongya Jia, Qing Nie +2
The last decade has witnessed a surge of theoretical and computational models to describe the dynamics of complex gene regulatory networks, and how these interactions can give rise…
Towards decoding the coupled decision-making of metabolism and epithelial-mesenchymal transition in cancer
Dongya Jia, Jun Hyoung Park, Harsimran Kaur +9
Cancer cells have the plasticity to adjust their metabolic phenotypes for survival and metastasis. During metastasis, a developmental program known as the epithelial-mesenchymal tr…
Decoding the mechanisms underlying cell-fate decision-making during stem cell differentiation by Random Circuit Perturbation
Bin Huang, Mingyang Lu, Madeline Galbraith +3
Stem cells can precisely and robustly undergo cellular differentiation and lineage commitment, referred to as stemness. However, how the gene network underlying stemness regulation…
Quantifying cancer epithelial-mesenchymal plasticity and its association with stemness and immune response
Dongya Jia, Xuefei Li, Federico Bocci +5
Cancer cells can acquire a spectrum of stable hybrid epithelial/mesenchymal (E/M) states during epithelial-mesenchymal transition (EMT). Cells in these hybrid E/M phenotypes often…
Modularity of the metabolic gene network as a prognostic biomarker for hepatocellular carcinoma
Fengdan Ye, Dongya Jia, Mingyang Lu +2
Abnormal metabolism is an emerging hallmark of cancer. Cancer cells utilize both aerobic glycolysis and oxidative phosphorylation (OXPHOS) for energy production and biomass synthes…
Distinguishing Mechanisms Underlying EMT Tristability
Dongya Jia, Mohit Kumar Jolly, Satyendra C. Tripathi +10
Background: The Epithelial-Mesenchymal Transition (EMT) endows epithelial-looking cells with enhanced migratory ability during embryonic development and tissue repair. EMT can also…