57 citations · 336 across the 51 of their papers we have counts for
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On the Ribosomal Density that Maximizes Protein Translation Rate
Yoram Zarai, Michael Margaliot, Tamir Tuller
During mRNA translation, several ribosomes attach to the same mRNA molecule simultaneously translating it into a protein. This pipelining increases the protein production rate. A n…
Optimal Down Regulation of mRNA Translation
Yoram Zarai, Michael Margaliot, Tamir Tuller
Down regulation of mRNA translation is an important problem in various bio-medical domains ranging from developing effective medicines for tumors and for viral diseases to developi…
Controllability analysis and control synthesis for the ribosome flow model
Yoram Zarai, Michael Margaliot, Eduardo D. Sontag +1
The ribosomal density along the coding region of the mRNA molecule affect various fundamental intracellular phenomena including: protein production rates, organismal fitness, ribos…
A Model for Competition for Ribosomes in the Cell
Alon Raveh, Michael Margaliot, Eduardo D. Sontag +1
Large-scale simultaneous mRNA translation and the resulting competition for the available ribosomes has important implications to the cell's functioning and evolution. Developing a…
On the Structure of the Initiation and Elongation Rates that Maximize Protein Production in the Ribosome Flow Model
Yoram Zarai, Michael Margaliot
Translation is a crucial step in gene expression. During translation, macromolecules called ribosomes "read" the mRNA strand in a sequential manner and produce a corresponding prot…
Sensitivity of mRNA Translation
Gilad Poker, Michael Margaliot, Tamir Tuller
Using the dynamic mean-field approximation of the totally asymmetric simple exclusion process (TASEP), we investigate the effect of small changes in the initiation, exit, and elong…
Maximizing Protein Translation Rate in the Nonhomogeneous Ribosome Flow Model: A Convex Optimization Approach
Gilad Poker, Yoram Zarai, Michael Margaliot +1
Translation is an important stage in gene expression. During this stage, macro-molecules called ribosomes travel along the mRNA strand linking amino-acids together in a specific or…
Maximizing Protein Translation Rate in the Ribosome Flow Model: the Homogeneous Case
Yoram Zarai, Michael Margaliot, Tamir Tuller
Gene translation is the process in which intracellular macro-molecules, called ribosomes, decode genetic information in the mRNA chain into the corresponding proteins. Gene transla…