166 citations · 881 across the 31 of their papers we have counts for
17 papers · 1 filter
Entropic contribution to phenotype fitness
Pablo Catalán, Juan Antonio García-Martín, Jacobo Aguirre +2
All possible phenotypes are not equally accessible to evolving populations. In fact, only phenotypes of large size, i.e. those resulting from many different genotypes, are found in…
The simple emergence of complex molecular function
Susanna Manrubia
At odds with a traditional view of molecular evolution that seeks a descent-with-modification relationship between functional sequences, new functions can emerge {\it de novo} with…
Individual risk-aversion responses tune epidemics to critical transmissibility ()
Susanna Manrubia, Damián H. Zanette
Changes in human behavior are increasingly recognized as a major determinant of epidemic dynamics. Although collective activity can be modified through imposed measures to control…
Predictability: Can the turning point and end of an expanding epidemic be precisely forecast?
Mario Castro, Saúl Ares, José A. Cuesta +1
No, they can't. Epidemic spread is characterized by exponentially growing dynamics, which are intrinsically unpredictable. The time at which the growth in the number of infected in…
From genotypes to organisms: State-of-the-art and perspectives of a cornerstone in evolutionary dynamics
Susanna Manrubia, José A. Cuesta, Jacobo Aguirre +15
Understanding how genotypes map onto phenotypes, fitness, and eventually organisms is arguably the next major missing piece in a fully predictive theory of evolution. We refer to t…
Statistical theory of phenotype abundance distributions: a test through exact enumeration of genotype spaces
Juan Antonio García-Martín, Pablo Catalán, Susanna Manrubia +1
The evolutionary dynamics of molecular populations are strongly dependent on the structure of genotype spaces. The map between genotype and phenotype determines how easily genotype…
Limited role of spatial self-structuring in emergent trade-offs during pathogen evolution
Victor Buendía, Miguel A. Muñoz, Susanna Manrubia
Pathogen transmission and virulence are main evolutionary variables broadly assumed to be linked through trade-offs. In well-mixed populations, these trade-offs are often ascribed…
On the networked architecture of genotype spaces and its critical effects on molecular evolution
Jacobo Aguirre, Pablo Catalán, José A. Cuesta +1
Evolutionary dynamics is often viewed as a subtle process of change accumulation that causes a divergence among organisms and their genomes. However, this interpretation is an inhe…
Distribution of phenotype sizes in sequence-to-structure genotype-phenotype maps
Susanna Manrubia, Jose A. Cuesta
An essential quantity to ensure evolvability of populations is the navigability of the genotype space. Navigability relies on the existence of sufficiently large genotype networks,…
Enumerating secondary structures and structural moieties for circular RNAs
José A. Cuesta, Susanna Manrubia
A quantitative characterization of the relationship between molecular sequence and structure is essential to improve our understanding of how function emerges. This particular geno…
Demography-based adaptive network model reproduces the spatial organization of human linguistic groups
Jose A. Capitan, Susanna Manrubia
The distribution of human linguistic groups presents a number of interesting and non-trivial patterns. The distributions of the number of speakers per language and the area each gr…
toyLIFE: a computational framework to study the multi-level organization of the genotype-phenotype map
Clemente F. Arias, Pablo Catalán, Susanna Manrubia +1
The genotype-phenotype map is an essential object in our understanding of organismal complexity and adaptive properties, determining at once genomic plasticity and those constraint…
Evolution on neutral networks accelerates the ticking rate of the molecular clock
Susanna Manrubia, José A. Cuesta
Large sets of genotypes give rise to the same phenotype because phenotypic expression is highly redundant. Accordingly, a population can accept mutations without altering its pheno…
The struggle for space: Viral extinction through competition for cells
Jose A. Cuesta, Jacobo Aguirre, Jose A. Capitan +1
The design of protocols to suppress the propagation of viral infections is an enduring enterprise, especially hindered by limited knowledge of the mechanisms through which extincti…
Neutral networks of genotypes: Evolution behind the curtain
Susanna C. Manrubia, Jose A. Cuesta
Our understanding of the evolutionary process has gone a long way since the publication, 150 years ago, of "On the origin of species" by Charles R. Darwin. The XXth Century witness…
Biodiversity in model ecosystems, II: Species assembly and food web structure
Ugo Bastolla, Michael Lässig, Susanna C. Manrubia +1
This is the second of two papers dedicated to the relationship between population models of competition and biodiversity. Here we consider species assembly models where the populat…
Biodiversity in model ecosystems, I: Coexistence conditions for competing species
Ugo Bastolla, Michael Lässig, Susanna C. Manrubia +1
This is the first of two papers where we discuss the limits imposed by competition to the biodiversity of species communities. In this first paper we study the coexistence of compe…