5 citations · 14 across the 6 of their papers we have counts for
3 papers · 1 filter
A Review of EMA Public Assessment Reports where Non-Proportional Hazards were Identified
Florian Klinglmueller, Norbert Benda, Tim Friede +8
While well-established methods for time-to-event data are available when the proportional hazards assumption holds, there is no consensus on the best approach under non-proportiona…
Design Considerations for a Phase II platform trial in Major Depressive Disorder
Michaela Maria Freitag, Dario Zocholl, Elias Laurin Meyer +5
Major Depressive Disorder (MDD) is one of the most common causes of disability worldwide. Unfortunately, about one-third of patients do not benefit sufficiently from available trea…
Adaptive Survival Trials
Dominic Magirr, Thomas Jaki, Franz Koenig +1
Mid-study design modifications are becoming increasingly accepted in confirmatory clinical trials, so long as appropriate methods are applied such that error rates are controlled.…