5 citations · 14 across the 6 of their papers we have counts for
6 papers
A two-step approach for analyzing time to event data under non-proportional hazards
Jonas Brugger, Tim Friede, Florian Klinglmüller +3
The log-rank test and the Cox proportional hazards model are commonly used to compare time-to-event data in clinical trials, as they are most powerful under proportional hazards. B…
A neutral comparison of statistical methods for time-to-event analyses under non-proportional hazards
Florian Klinglmüller, Tobias Fellinger, Franz König +10
While well-established methods for time-to-event data are available when the proportional hazards assumption holds, there is no consensus on the best inferential approach under non…
Design Considerations for a Phase II platform trial in Major Depressive Disorder
Michaela Maria Freitag, Dario Zocholl, Elias Laurin Meyer +5
Major Depressive Disorder (MDD) is one of the most common causes of disability worldwide. Unfortunately, about one-third of patients do not benefit sufficiently from available trea…
Simultaneous inference procedures for the comparison of multiple characteristics of two survival functions
Robin Ristl, Heiko Götte, Armin Schüler +2
Survival time is the primary endpoint of many randomized controlled trials, and a treatment effect is typically quantified by the hazard ratio under the assumption of proportional…
Online control of the False Discovery Rate in group-sequential platform trials
Sonja Zehetmayer, Martin Posch, Franz Koenig
When testing multiple hypotheses, a suitable error rate should be controlled even in exploratory trials. Conventional methods to control the False Discovery Rate (FDR) assume that…
Adaptive Survival Trials
Dominic Magirr, Thomas Jaki, Franz Koenig +1
Mid-study design modifications are becoming increasingly accepted in confirmatory clinical trials, so long as appropriate methods are applied such that error rates are controlled.…