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stat.ME2025
A Two-Step Test to Identify Zero-Inflated Biomarkers in Early-Phase Clinical Trials
Nan Miles Xi, Lin Wang
In early-phase clinical trials, a predictive biomarker may identify subgroups that benefit from an experimental therapy, even when the overall average treatment effect is negligibl…
stat.ME2025
Synergy-Informed Design of Platform Trials for Combination Therapies
Nan Miles Xi, Man Mandy Jin, Lin Wang +1
Combination drug therapies hold significant promise for enhancing treatment efficacy, particularly in fields such as oncology, immunotherapy, and infectious diseases. However, desi…