4 papers
Leveraging Large Language Models for Rare Disease Named Entity Recognition
Nan Miles Xi, Yu Deng, Lin Wang
Named Entity Recognition (NER) in the rare disease domain poses unique challenges due to limited labeled data, semantic ambiguity between entity types, and long-tail distributions.…
A Two-Step Test to Identify Zero-Inflated Biomarkers in Early-Phase Clinical Trials
Nan Miles Xi, Lin Wang
In early-phase clinical trials, a predictive biomarker may identify subgroups that benefit from an experimental therapy, even when the overall average treatment effect is negligibl…
Synergy-Informed Design of Platform Trials for Combination Therapies
Nan Miles Xi, Man Mandy Jin, Lin Wang +1
Combination drug therapies hold significant promise for enhancing treatment efficacy, particularly in fields such as oncology, immunotherapy, and infectious diseases. However, desi…
Understanding Sarcoidosis Using Large Language Models and Social Media Data
Nan Miles Xi, Hong-Long Ji, Lin Wang
Sarcoidosis is a rare inflammatory disease characterized by the formation of granulomas in various organs. The disease presents diagnostic and treatment challenges due to its diver…