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physics.bio-ph2025
Ambiguous signals and efficient codes
Marianne Bauer, William Bialek
In many biological networks the responses of individual elements are ambiguous. We consider a scenario in which many sensors respond to a shared signal, each with limited informati…
physics.bio-ph2025
Unifying Theories in High-Dimensional Biology: Approaches, Challenges and Opportunities
Marianne Bauer, Akshit Goyal, Sidhartha Goyal +19
Across biological subdisciplines, the last decade has seen an explosion of high-dimensional datasets, including datasets for cells, species, immune systems, neurons and behaviour.…
physics.bio-ph2025
Weak transcription factor clustering at binding sites can facilitate information transfer from molecular signals
Tamara MijatoviÄ, Aimée R. Kok, Merlijn Brüggen +2
Transcription factor concentrations provide signals to cells that allow them to regulate gene expression to make correct cell fate decisions. Calculations for noise bounds in gene…