253 citations · 559 across the 15 of their papers we have counts for
3 papers · 1 filter
Pluripotency, differentiation, and reprogramming: A gene expression dynamics model with epigenetic feedback regulation
Tadashi Miyamoto, Chikara Furusawa, Kunihiko Kaneko
Characterization of pluripotent states, in which cells can both self-renew and differentiate, and the irreversible loss of pluripotency are important research areas in developmenta…
A generic mechanism for adaptive growth rate regulation
Chikara Furusawa, Kunihiko Kaneko
How can a microorganism adapt to a variety of environmental conditions despite there exists a limited number of signal transduction machineries? We show that for any growing cells…
Ubiquity of Log-normal Distributions in Intra-cellular Reaction Dynamic
Chikara Furusawa, Takao Suzuki, Akiko Kashiwagi +2
The discovery of two fundamental laws concerning cellular dynamics with recursive growth is reported. First, the chemical abundances measured over many cells are found to obey a lo…