253 citations · 559 across the 15 of their papers we have counts for
15 papers
Rare-Event Sampling Analysis Uncovers the Fitness Landscape of the Genetic Code
Yuji Omachi, Nen Saito, Chikara Furusawa
The genetic code refers to a rule that maps 64 codons to 20 amino acids. Nearly all organisms, with few exceptions, share the same genetic code, the standard genetic code (SGC). Wh…
Prediction of Cross-Fitness for Adaptive Evolution to Different Environmental Conditions: Consequence of Phenotypic Dimensional Reduction
Takuya U. Sato, Chikara Furusawa, Kunihiko Kaneko
How adaptive evolution to one environmental stress improves or suppresses adaptation to another is an important problem in evolutionary biology. For instance, in microbiology, the…
Direction and Constraint in Phenotypic Evolution: Dimension Reduction and Global Proportionality in Phenotype Fluctuation and Responses
Kunihiko Kaneko, Chikara Furusawa
A macroscopic theory for describing cellular states during steady-growth is presented, which is based on the consistency between cellular growth and molecular replication, as well…
Formation of Dominant Mode by Evolution in Biological Systems
Chikara Furusawa, Kunihiko Kaneko
Constraints on changes in expression levels across all cell components imposed by the steady growth of cells have recently been discussed both experimentally and theoretically. By…
Pluripotency, differentiation, and reprogramming: A gene expression dynamics model with epigenetic feedback regulation
Tadashi Miyamoto, Chikara Furusawa, Kunihiko Kaneko
Characterization of pluripotent states, in which cells can both self-renew and differentiate, and the irreversible loss of pluripotency are important research areas in developmenta…
Global Relationships in Fluctuation and Response in Adaptive Evolution
Chikara Furusawa, Kunihiko Kaneko
Cells generally change their internal state to adapt to an environmental change, and accordingly evolve in response to the new conditions. This process involves phenotypic changes…