475 citations · 1.5k across the 19 of their papers we have counts for
20 papers
A mathematical modelling of rheumatoid arthritis
Pascal Azerad, Oana Iosifescu, Andrea Parmeggiani +3
We developed a mathematical model to describe the inflammatory dynamics during arthritis development and resolution, focusing on the interaction between three key immune cell popul…
Signature of (anti)cooperativity in the stochastic fluctuations of small systems: application to the bacterial flagellar motor
María-José Franco-Oñate, Andrea Parmeggiani, Jérôme Dorignac +6
The cooperative binding of molecular agents onto a substrate is pervasive in living systems. To study whether a system shows cooperativity, one can rely on a fluctuation analysis o…
Modelling the effect of ribosome mobility on the rate of protein synthesis
Olivier Dauloudet, Izaak Neri, Jean-Charles Walter +3
Translation is one of the main steps in the synthesis of proteins. It consists of ribosomes that translate sequences of nucleotides encoded on mRNA into polypeptide sequences of am…
Stochastic modelling of collective motor protein transport through a crossing of microtubules
Adélaïde Raguin, Norbert Kern, Andrea Parmeggiani
The cytoskeleton in eukaryotic cells plays several crucial roles. In terms of intracellular transport, motor proteins use the cytoskeletal filaments as a backbone along which they…
Modeling supercoiled DNA interacting with an anchored cluster of proteins: towards a quantitative estimation of chromosomal DNA supercoiling
Jean-Charles Walter, Thibaut Lepage, Jérôme Dorignac +5
We investigate the measurement of DNA supercoiling density () along chromosomes using interaction frequencies between DNA and DNA-anchored clusters of proteins. Specifically, we…
Looping and Clustering model for the organization of protein-DNA complexes on the bacterial genome
Jean-Charles Walter, Nils-Ole Walliser, Gabriel David +6
The bacterial genome is organized in a structure called the nucleoid by a variety of associated proteins. These proteins can form complexes on DNA that play a central role in vario…