4 papers · 1 filter
The impact of coarsening an exposure on partial identifiability in instrumental variable settings
Erin E. Gabriel, Michael C. Sachs, Arvid Sjölander
In instrumental variable (IV) settings, such as in imperfect randomized trials and observational studies with Mendelian randomization, one may encounter a continuous exposure, the…
Sharp symbolic nonparametric bounds for measures of benefit in observational and imperfect randomized studies with ordinal outcomes
Erin E Gabriel, Michael C Sachs, Andreas Kryger Jensen
The probability of benefit is a valuable and important measure of treatment effect, which has advantages over the average treatment effect. Particularly for an ordinal outcome, it…
Flexible evaluation of surrogacy in Bayesian adaptive platform studies
Michael C Sachs, Erin E Gabriel, Alessio Crippa +1
Trial level surrogates are useful tools for improving the speed and cost effectiveness of trials, but surrogates that have not been properly evaluated can cause misleading results.…
Sharp nonparametric bounds for decomposition effects with two binary mediators
Erin E Gabriel, Michael C Sachs, Arvid Sjölander
In randomized trials, once the total effect of the intervention has been estimated, it is often of interest to explore mechanistic effects through mediators along the causal pathwa…