3 papers
q-bio.PE2026
Inference of germinal center evolutionary dynamics via simulation-based deep learning
Duncan K Ralph, Athanasios G Bakis, Jared Galloway +6
B cells and the antibodies they produce are vital to health and survival, motivating research on the details of the mutational and evolutionary processes in the germinal centers (G…
stat.ME2026
Bayesian inference of antibody evolutionary dynamics using multitype branching processes
Athanasios G. Bakis, Ashni A. Vora, Tatsuya Araki +8
When our immune system encounters foreign antigens (i.e., from pathogens), the B cells that produce our antibodies undergo a cyclic process of proliferation, mutation, and selectio…
q-bio.PE2024
Exact and efficient phylodynamic simulation from arbitrarily large populations
Michael Celentano, William S. DeWitt, Sebastian Prillo +1
Many biological studies involve inferring the evolutionary history of a sample of individuals from a large population and interpreting the reconstructed tree. Such an ascertained t…