239 citations · 3.6k across the 108 of their papers we have counts for
3 papers · 1 filter
The fitness landscapes of translation
Mario Josupeit, Joachim Krug
Motivated by recent experiments on an antibiotic resistance gene, we investigate genetic interactions between synonymous mutations in the framework of exclusion models of translati…
Distribution of the number of fitness maxima in Fisher's Geometric Model
Su-Chan Park, Sungmin Hwang, Joachim Krug
Fisher's geometric model describes biological fitness landscapes by combining a linear map from the discrete space of genotypes to an -dimensional Euclidean phenotype space with…
From genotypes to organisms: State-of-the-art and perspectives of a cornerstone in evolutionary dynamics
Susanna Manrubia, José A. Cuesta, Jacobo Aguirre +15
Understanding how genotypes map onto phenotypes, fitness, and eventually organisms is arguably the next major missing piece in a fully predictive theory of evolution. We refer to t…