62 citations · 75 across the 2 of their papers we have counts for
2 papers
q-bio.PE2013★ 13 cited
The inevitability of unconditionally deleterious substitutions during adaptation
David M. McCandlish, Charles L. Epstein, Joshua B. Plotkin
Studies on the genetics of adaptation typically neglect the possibility that a deleterious mutation might fix. Nonetheless, here we show that, in many regimes, the first substituti…
q-bio.PE2012★ 62 cited
Epistasis not needed to explain low dN/dS
David M. McCandlish, Etienne Rajon, Premal Shah +2
An important question in molecular evolution is whether an amino acid that occurs at a given position makes an independent contribution to fitness, or whether its effect depends on…