221 citations · 254 across the 3 of their papers we have counts for
3 papers
The diversity of evolutionary dynamics on epistatic versus non-epistatic fitness landscapes
David M. McCandlish, Jakub Otwinowski, Joshua B. Plotkin
The class of epistatic fitness landscapes is much more diverse than the class of non-epistatic landscapes, and so it stands to reason that there exist dynamical phenomena that can…
Historical contingency and entrenchment in protein evolution under purifying selection
Premal Shah, David M. McCandlish, Joshua B. Plotkin
The fitness contribution of an allele at one genetic site may depend on alleles at other sites, a phenomenon known as epistasis. Epistasis can profoundly influence the process of e…
Formal properties of the probability of fixation: identities, inequalities and approximations
David M. McCandlish, Charles L. Epstein, Joshua B. Plotkin
The formula for the probability of fixation of a new mutation is widely used in theoretical population genetics and molecular evolution. Here we derive a series of identities, ineq…