253 citations · 3k across the 163 of their papers we have counts for
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Dynamical Theory for Adaptive Systems
Tuan Minh Pham, Kunihiko Kaneko
The study of adaptive dynamics, involving many degrees of freedom on two separated timescales, one for fast changes of state variables and another for the slow adaptation of parame…
Evolutionary Shaping of Low-Dimensional Path Facilitates Robust and Plastic Switching Between Phenotypes
Ayaka Sakata, Kunihiko Kaneko
Biological systems must be robust for stable function against perturbations, but robustness alone is not sufficient. The ability to switch between appropriate states (phenotypes) i…
Double-replica theory for evolution of genotype-phenotype interrelationship
Tuan Minh Pham, Kunihiko Kaneko
The relationship between genotype and phenotype plays a crucial role in determining the function and robustness of biological systems. Here the evolution progresses through the cha…
Prediction of Cross-Fitness for Adaptive Evolution to Different Environmental Conditions: Consequence of Phenotypic Dimensional Reduction
Takuya U. Sato, Chikara Furusawa, Kunihiko Kaneko
How adaptive evolution to one environmental stress improves or suppresses adaptation to another is an important problem in evolutionary biology. For instance, in microbiology, the…
Direction and Constraint in Phenotypic Evolution: Dimension Reduction and Global Proportionality in Phenotype Fluctuation and Responses
Kunihiko Kaneko, Chikara Furusawa
A macroscopic theory for describing cellular states during steady-growth is presented, which is based on the consistency between cellular growth and molecular replication, as well…
A scaling law of multilevel evolution: how the balance between within- and among-collective evolution is determined
Nobuto Takeuchi, Namiko Mitarai, Kunihiko Kaneko
Numerous living systems are hierarchically organised, whereby replicating components are grouped into reproducing collectives -- e.g., organelles are grouped into cells, and cells…
Evolutionary dimension reduction in phenotypic space
Takuya U. Sato, Kunihiko Kaneko
In general, cellular phenotypes, as measured by concentrations of cellular components, involve large degrees of freedom. However, recent measurement has demonstrated that phenotypi…
The advantage of leakage of essential metabolites and resultant symbiosis of diverse species
Jumpei F Yamagishi, Nen Saito, Kunihiko Kaneko
Microbial communities display extreme diversity. A variety of strains or species coexist even when limited by a single resource. It has been argued that metabolite secretion create…
Formation of Dominant Mode by Evolution in Biological Systems
Chikara Furusawa, Kunihiko Kaneko
Constraints on changes in expression levels across all cell components imposed by the steady growth of cells have recently been discussed both experimentally and theoretically. By…
Stronger selection can slow down evolution driven by recombination on a smooth fitness landscape
Masahiko Ueda, Nobuto Takeuchi, Kunihiko Kaneko
Stronger selection implies faster evolution---that is, the greater the force, the faster the change. This apparently self-evident proposition, however, is derived under the assumpt…
Global Relationships in Fluctuation and Response in Adaptive Evolution
Chikara Furusawa, Kunihiko Kaneko
Cells generally change their internal state to adapt to an environmental change, and accordingly evolve in response to the new conditions. This process involves phenotypic changes…
Evolution-Development Congruence in Pattern Formation Dynamics: Bifurcations in Gene Expressions and Regulation of Networks Structures
Takahiro Kohsokabe, Kunihiko Kaneko
Search for possible relationships between phylogeny and ontogeny is one of the most important issues in the field of evolutionary developmental biology. By representing development…
Evolution of Robustness and Plasticity under Environmental Fluctuation: Formulation in terms of Phenotypic Variances
Kunihiko Kaneko
The characterization of plasticity, robustness, and evolvability, an important issue in biology, is studied in terms of phenotypic fluctuations. By numerically evolving gene regula…
Evolution of Genetic Redundancy : The Relevance of Complexity in Genotype-Phenotype Mapping
Nen Saito, Shuji Ishihara, Kunihiko Kaneko
Genetic redundancy is ubiquitous and can be found in any organism. However, it has been argued that genetic redundancy reduces total population fitness, and therefore, redundancy i…
The Baldwin effect under multi-peaked fitness landscapes: Phenotypic fluctuation accelerates evolutionary rate
Nen Saito, Shuji Ishihara, Kunihiko Kaneko
Phenotypic fluctuations and plasticity can generally affect the course of evolution, a process known as the Baldwin effect. Several studies have recast this effect and claimed that…
Relationship among Phenotypic Plasticity, Genetic and Epigenetic Fluctuations, Robustness, and Evolovability; Waddington's Legacy revisited under the Spirit of Einstein
Kunihiko Kaneko
Questions on possible relationship between phenotypic plasticity and evolvability, as well as that between robustness and evolution have been addressed over decades in the field of…
Shaping Robust System through Evolution
Kunihiko Kaneko
Biological functions are generated as a result of developmental dynamics that form phenotypes governed by genotypes. The dynamical system for development is shaped through genetic…
Evolution Equation of Phenotype Distribution: General Formulation and Application to Error Catastrophe
Katsuhiko Sato, Kunihiko Kaneko
An equation describing the evolution of phenotypic distribution is derived using methods developed in statistical physics. The equation is solved by using the singular perturbation…
Diversity as a product of interspecial interactions
Daniel Lawson, Henrik Jeldtoft Jensen, Kunihiko Kaneko
We demonstrate diversification rather than optimisation for highly interacting organisms in a well mixed biological system by means of a simple model and reference to experiment, a…
Evolutionary origin of power-laws in Biochemical Reaction Network; embedding abundance distribution into topology
Chikara Furusawa, Kunihiko Kaneko
The evolutionary origin of universal statistics in biochemical reaction network is studied, to explain the power-law distribution of reaction links and the power-law distributions…