136 citations · 778 across the 45 of their papers we have counts for
45 papers
Inferring and predicting Fried physical frailty phenotype deficits
Glen Pridham, Kenneth Rockwood, Andrew Rutenberg
We predict the Fried physical frailty phenotype health deficits (FPFP5: slow gait, weakness, weight loss, low activity, and exhaustion) using two measures of frailty: frailty index…
Aging health dynamics cross a tipping point near age 75
Glen Pridham, Kenneth Rockwood, Andrew Rutenberg
Aging includes both continuous gradual decline, such as in physiological function, together with major deficit onset events such as morbidity, disability and ultimately death. Thes…
Systems-level health of patients living with end-stage kidney disease using standard lab values
Glen Pridham, Karthik K. Tennankore, Kenneth Rockwood +2
We present a systems-level analysis of end-stage kidney disease (ESKD) with a dynamical network analysis of 14 commonly measured blood-based biomarkers in patients undergoing regul…
Dynamical network stability analysis of multiple biological ages provides a framework for understanding the aging process
Glen Pridham, Andrew D. Rutenberg
Widespread interest in non-destructive biomarkers of aging has led to a curse of plenty: a multitude of biological ages that each proffers a 'true' health-adjusted age of an indivi…
Network dynamical stability analysis reveals key "mallostatic" natural variables that erode homeostasis and drive age-related decline of health
Glen Pridham, Andrew D. Rutenberg
Using longitudinal study data, we dynamically model how aging affects homeostasis in both mice and humans. We operationalize homeostasis as a multivariate mean-reverting stochastic…
Modelling disease impact: lifespan reduction is greatest for young adults in an exogenous damage model of disease
Rebecca Tobin, Glen Pridham, Andrew D. Rutenberg
We model the effects of disease and other exogenous damage during human aging. Even when the exogenous damage is repaired at the end of acute disease, propagated secondary damage r…