169 citations · 983 across the 15 of their papers we have counts for
15 papers
Reassessment of the basis of cell size control based on analysis of cell-to-cell variability
Giuseppe Facchetti, Benjamin Knapp, Fred Chang +1
Fundamental mechanisms governing cell size control and homeostasis are still poorly understood. The relationship between sizes at division and birth in single cells is used as a me…
Centre-finding in E. coli and the role of mathematical modelling: past, present and future
Sean M. Murray, Martin Howard
We review the key role played by mathematical modelling in elucidating two centre-finding patterning systems in E. coli: midcell division positioning by the MinCDE system and DNA p…
Arabidopsis plants perform arithmetic division to prevent starvation at night
Antonio Scialdone, Sam T. Mugford, Doreen Feike +5
Photosynthetic starch reserves that accumulate in Arabidopsis leaves during the day decrease approximately linearly with time at night to support metabolism and growth. We find tha…
When it Pays to Rush: Interpreting Morphogen Gradients Prior to Steady-State
Timothy E Saunders, Martin Howard
During development, morphogen gradients precisely determine the position of gene expression boundaries despite the inevitable presence of fluctuations. Recent experiments suggest t…
The role of spatial averaging in the precision of gene expression patterns
Thorsten Erdmann, Martin Howard, Pieter Rein ten Wolde
During embryonic development, differentiating cells respond via gene expression to positional cues from morphogen gradients. While gene expression is often highly erratic, embryoni…
Morphogen Profiles Can Be Optimised to Buffer Against Noise
Timothy E Saunders, Martin Howard
Morphogen profiles play a vital role in biology by specifying position in embryonic development. However, the factors that influence the shape of a morphogen profile remain poorly…