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q-bio.MN2025
Bifunctional enzyme action as a source of robustness in biochemical reaction networks: a novel hypergraph approach
Badal Joshi, Tung D. Nguyen
Substrate modification networks are ubiquitous in living, biochemical systems. A higher-level hypergraph "skeleton" captures key information about which substrates are transformed…
q-bio.MN2023
Bifunctional enzyme provides absolute concentration robustness in multisite covalent modification networks
Badal Joshi, Tung D. Nguyen
Biochemical covalent modification networks exhibit a remarkable suite of steady state and dynamical properties such as multistationarity, oscillations, ultrasensitivity and absolut…