7 citations · 7 across the 2 of their papers we have counts for
6 papers · 1 filter
Effective interface conditions for continuum mechanical models describing the invasion of multiple cell populations through thin membranes
Chiara Giverso, Tommaso Lorenzi, Luigi Preziosi
We consider a continuum mechanical model for the migration of multiple cell populations through parts of tissue separated by thin membranes. In this model, cells belonging to diffe…
From a discrete model of chemotaxis with volume-filling to a generalised Patlak-Keller-Segel model
Federica Bubba, Tommaso Lorenzi, Fiona R Macfarlane
We present a discrete model of chemotaxis whereby cells responding to a chemoattractant are seen as individual agents whose movement is described through a set of rules that result…
A structured population model of clonal selection in acute leukemias with multiple maturation stages
Tommaso Lorenzi, Anna Marciniak-Czochra, Thomas Stiehl
Recent progress in genetic techniques has shed light on the complex co-evolution of malignant cell clones in leukemias. However, several aspects of clonal selection still remain un…
Asymptotic analysis of selection-mutation models in the presence of multiple fitness peaks
Tommaso Lorenzi, Camille Pouchol
We study the long-time behaviour of phenotype-structured models describing the evolutionary dynamics of asexual species whose phenotypic fitness landscape is characterised by multi…
From individual-based mechanical models of multicellular systems to free-boundary problems
Tommaso Lorenzi, Philip J. Murray, Mariya Ptashnyk
In this paper we present an individual-based mechanical model that describes the dynamics of two contiguous cell populations with different proliferative and mechanical characteris…
Populational adaptive evolution, chemotherapeutic resistance and multiple anti-cancer therapies
Alexander Lorz, Tommaso Lorenzi, Michael E. Hochberg +2
Resistance to chemotherapies, particularly to anticancer treatments, is an increasing medical concern. Among the many mechanisms at work in cancers, one of the most important is th…