56 citations · 107 across the 14 of their papers we have counts for
5 papers · 1 filter
An introduction to reconstructing ancestral genomes
Lior Pachter
Recent advances in high-throughput genomics technologies have resulted in the sequencing of large numbers of (near) complete genomes. These genome sequences are being mined for imp…
Subtree power analysis finds optimal species for comparative genomics
Jon D. McAuliffe, Michael I. Jordan, Lior Pachter
Sequence comparison across multiple organisms aids in the detection of regions under selection. However, resource limitations require a prioritization of genomes to be sequenced. T…
Needed for completion of the human genome: hypothesis driven experiments and biologically realistic mathematical models
Roderic Guigo, Ewan Birney, Michael Brent +5
With the sponsorship of ``Fundacio La Caixa'' we met in Barcelona, November 21st and 22nd, to analyze the reasons why, after the completion of the human genome sequence, the identi…
Parametric Inference for Biological Sequence Analysis
Lior Pachter, Bernd Sturmfels
One of the major successes in computational biology has been the unification, using the graphical model formalism, of a multitude of algorithms for annotating and comparing biologi…
MAVID: Constrained ancestral alignment of multiple sequences
Nicolas Bray, Lior Pachter
We describe a new global multiple alignment program capable of aligning a large number of genomic regions. Our progressive alignment approach incorporates the following ideas: maxi…