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Ancient human genomes suggest three ancestral populations for present-day Europeans
Iosif Lazaridis, Nick Patterson, Alissa Mittnik +117
We sequenced genomes from a 7,000 year old early farmer from Stuttgart in Germany, an 8,000 year old hunter-gatherer from Luxembourg, and seven 8,000 year old hun…
A path integral formulation of the Wright-Fisher process with genic selection
Joshua G. Schraiber
The Wright-Fisher process with selection is an important tool in population genetics theory. Traditional analysis of this process relies on the diffusion approximation. The diffusi…
Analysis and rejection sampling of Wright-Fisher diffusion bridges
Joshua G. Schraiber, Robert C. Griffiths, Steven N. Evans
We investigate the properties of a Wright-Fisher diffusion process started from frequency x at time 0 and conditioned to be at frequency y at time T. Such a process is called a bri…
Inferring evolutionary histories of pathway regulation from transcriptional profiling data
Joshua G. Schraiber, Yulia Mostovoy, Tiffany Y. Hsu +1
One of the outstanding challenges in comparative genomics is to interpret the evolutionary importance of regulatory variation between species. Rigorous molecular evolution-based me…