1.5k citations · 1.6k across the 6 of their papers we have counts for
7 papers
Bayesian nonparametric strategies for power maximization in rare variants association studies
Lorenzo Masoero, Joshua Schraiber, Tamara Broderick
Rare variants are hypothesized to be largely responsible for heritability and susceptibility to disease in humans. So rare variants association studies hold promise for understandi…
Bayesian inference of natural selection from allele frequency time series
Joshua G. Schraiber, Steven N. Evans, Montgomery Slatkin
The advent of accessible ancient DNA technology now allows the direct ascertainment of allele frequencies in ancestral populations, thereby enabling the use of allele frequency tim…
Ancient human genomes suggest three ancestral populations for present-day Europeans
Iosif Lazaridis, Nick Patterson, Alissa Mittnik +117
We sequenced genomes from a 7,000 year old early farmer from Stuttgart in Germany, an 8,000 year old hunter-gatherer from Luxembourg, and seven 8,000 year old hun…
A path integral formulation of the Wright-Fisher process with genic selection
Joshua G. Schraiber
The Wright-Fisher process with selection is an important tool in population genetics theory. Traditional analysis of this process relies on the diffusion approximation. The diffusi…
Analysis and rejection sampling of Wright-Fisher diffusion bridges
Joshua G. Schraiber, Robert C. Griffiths, Steven N. Evans
We investigate the properties of a Wright-Fisher diffusion process started from frequency x at time 0 and conditioned to be at frequency y at time T. Such a process is called a bri…
Inferring evolutionary histories of pathway regulation from transcriptional profiling data
Joshua G. Schraiber, Yulia Mostovoy, Tiffany Y. Hsu +1
One of the outstanding challenges in comparative genomics is to interpret the evolutionary importance of regulatory variation between species. Rigorous molecular evolution-based me…
Genomic tests of variation in inbreeding among individuals and among chromosomes
Joshua G. Schraiber, Stephannie Shih, Montgomery Slatkin
We examine the distribution of heterozygous sites in nine European and nine Yoruban individuals whose genomic sequences were made publicly available by Complete Genomics. We show t…