148 citations · 747 across the 25 of their papers we have counts for
4 papers · 1 filter
Polymer compaction and bridging-induced clustering of protein-inspired patchy particles
C. A. Brackley
There are many proteins or protein complexes which have multiple DNA binding domains. This allows them to bind to multiple points on a DNA molecule (or chromatin fibre) at the same…
Chromosome Compaction and Chromatin Stiffness Enhance Diffusive Loop Extrusion by Slip-Link Proteins
Andrea Bonato, Chris A. Brackley, James Johnson +2
We use Brownian dynamics simulations to study the formation of chromatin loops through diffusive sliding of slip-link-like proteins, mimicking the behaviour of cohesin molecules. W…
Transcription-driven DNA Supercoiling: Non-Equilibrium Dynamics and Action-at-a-distance
Y. A. G. Fosado, D. Michieletto, C. A. Brackley +1
We study the effect of transcription on the kinetics of DNA supercoiling in 3D by means of Brownian dynamics simulations of a single nucleotide resolution coarse-grained model for…
Transcriptional bursts in a non-equilibrium model for gene regulation by supercoiling
Marco Ancona, Alessandro Bentivoglio, Chris A. Brackley +2
We analyse transcriptional bursting within a stochastic non-equilibrium model which accounts for the coupling between the dynamics of DNA supercoiling and gene transcription. We fi…