94 citations · 411 across the 44 of their papers we have counts for
4 papers · 2 filters
The Emergence of Scaling in Sequence-based Physical Models of Protein Evolution
Eric J. Deeds, Eugene I. Shakhnovich
It has recently been discovered that many biological systems, when represented as graphs, exhibit a scale-free topology. One such system is the set of structural relationships amon…
Semiconservative replication in the quasispecies model II: Generalization to arbitrary lesion repair probabilities
Emmanuel Tannenbaum, James L. Sherley, Eugene I. Shakhnovich
This paper extends the semiconservative quasispecies equations to account for arbitrary post-replication lesion repair efficiency. Such an extension could be an important tool for…
Host-Parasite Co-evolution and Optimal Mutation Rates for Semi-conservative Quasispecies
Yisroel Brumer, Eugene I. Shakhnovich
In this paper, we extend a model of host-parasite co-evolution to incorporate the semi-conservative nature of DNA replication for both the host and the parasite. We find that the o…
A Selective Advantage for Conservative Viruses
Yisroel Brumer, Eugene I. Shakhnovich
In this letter we study the full semi-conservative treatment of a model for the co-evolution of a virus and an adaptive immune system. Regions of viability are calculated for both…