21 citations · 27 across the 16 of their papers we have counts for
4 papers · 1 filter
The Error and Repair Catastrophes: A Two-Dimensional Phase Diagram in the Quasispecies Model
Emmanuel Tannenbaum, Eugene I. Shakhnovich
This paper develops a two gene, single fitness peak model for determining the equilibrium distribution of genotypes in a unicellular population which is capable of genetic damage r…
Equilibrium Distribution of Mutators in the Single Fitness Peak Model
Emmanuel Tannenbaum, Eric Deeds, Eugene I. Shakhnovich
This paper develops an analytically tractable model for determining the equilibrium distribution of mismatch repair deficient strains in unicellular populations. The approach is ba…
Understanding hierarchical protein evolution from first principles
Nikolay V. Dokholyan, Eugene I. Shakhnovich
We propose a model that explains the hierarchical organization of proteins in fold families. The model, which is based on the evolutionary selection of proteins by their native sta…
Understanding conserved amino acids in proteins
Nikolay V. Dokholyan, Leonid A. Mirny, Eugene I. Shakhnovich
It has been conjectured that evolution exerted pressure to preserve amino acids bearing thermodynamic, kinetic, and functional roles. In this letter we show that the physical requi…