326 citations · 704 across the 12 of their papers we have counts for
12 papers
Emergence of mutationally robust proteins in a microscopic model of evolution
Konstantin B. Zeldovich, Eugene I. Shakhnovich
The ability to absorb mutations while retaining structure and function, or mutational robustness, is a remarkable property of natural proteins. In this Letter, we use a computation…
Diversity against adversity: How adaptive immunity evolves potent antibodies
Muyoung Heo, Konstantin B. Zeldovich, Eugene I. Shakhnovich
How does immune system evolve functional proteins - potent antibodies - in such a short time? We address this question using a microscopic, protein-level, sequence-based model of h…
Emergence of clonal selection and affinity maturation in an ab initio microscopic model of immunity
Muyoung Heo, Konstantin B. Zeldovich, Eugene I. Shakhnovich
Mechanisms of immunity, and of the host-pathogen interactions in general are among the most fundamental problems of medicine, ecology, and evolution studies. Here, we present a mic…
The Hypercube of Life: How Protein Stability Imposes Limits on Organism Complexity and Speed of Molecular Evolution
Konstantin Zeldovich, Peiqiu Chen, Eugene Shakhnovich
Classical population genetics a priori assigns fitness to alleles without considering molecular or functional properties of proteins that these alleles encode. Here we study popula…
A first-principles model of early evolution: Emergence of gene families, species and preferred protein folds
Konstantin Zeldovich, Peiqiu Chen, Boris Shakhnovich +1
In this work we develop a microscopic physical model of early evolution, where phenotype,organism life expectancy, is directly related to genotype, the stability of its proteins in…
The folding mechanics of a knotted protein
Stefan Wallin, Konstantin B Zeldovich, Eugene I Shakhnovich
An increasing number of proteins are being discovered with a remarkable and somewhat surprising feature, a knot in their native structures. How the polypeptide chain is able to kno…