67 citations · 436 across the 23 of their papers we have counts for
23 papers
Spontaneous polarization for protrusion-driven cell crawling
Pierre Recho
We propose a minimal one-dimensional continuum model for the spontaneous initiation of protrusion-driven cell crawling on a rigid substrate. The cell cytoskeleton is represented as…
Optimal crawling: from mechanical to chemical actuation
Pierre Recho, Lev Truskinovsky
Taking inspiration from the crawling motion of biological cells on a substrate, we consider a physical model of self-propulsion where the spatio-temporal driving can involve both,…
Mechanics and thermodynamics of contractile entropic biopolymer networks
Antoine Jallon, Pierre Recho, Jocelyn Étienne
Contractile biopolymer networks, such as the actomyosin meshwork of animal cells, are ubiquitous in living organisms. The active gel theory, which provides the thermodynamic framew…
Initiation of motility on a compliant substrate
Jocelyn Étienne, Pierre Recho
The conditions under which biological cells switch from a static to a motile state are fundamental to the understanding of many healthy and pathological processes. In this paper, w…
Cell motility as an energy minimization process
Haythem Chelly, Pierre Recho
The dynamics of active matter driven by interacting molecular motors has a non-potential structure at the local scale. However, we show that there exists a quasi-potential effectiv…
Creating Multimodal Interactive Agents with Imitation and Self-Supervised Learning
DeepMind Interactive Agents Team, Josh Abramson, Arun Ahuja +22
A common vision from science fiction is that robots will one day inhabit our physical spaces, sense the world as we do, assist our physical labours, and communicate with us through…
Chemo-mechanical model of a cell as a stochastic active gel
Vikram Deshpande, Antonio DeSimone, Robert McMeeking +1
While it is commonly observed that the shape dynamics of mammalian cells can undergo large random fluctuations, theoretical models aiming at capturing cell mechanics often focus on…
Mechanical behavior of multi-cellular spheroids under osmotic compression
Monika Dolega, Giuseppe Zurlo, Magali Le Goff +5
The internal and external mechanical environment plays an important role in tumorogenesis. As a proxy of an avascular early state tumor, we use multicellular spheroids, a composite…
Mechanical Feedback in Regulating the Size of Growing Multicellular Spheroids
Alexander Erlich, Pierre Recho
The mechanism by which cells measure the dimension of the organ in which they are embedded, and slow down their growth when the final size is reached, is a long-standing problem of…
A tug-of-war between stretching and bending in living cell sheets
Pierre Recho, Jonathan Fouchard, Tom Wyatt +3
The balance between stretching and bending deformations characterizes shape transitions of thin elastic sheets. While stretching dominates the mechanical response in tension, bendi…
Active gel segment behaving as an active particle
Pierre Recho, Thibaut Putelat, Lev Truskinovsky
We reduce a one-dimensional model of an active segment (AS), which is used, for instance, in the description of contraction driven cell motility on tracks, to a zero-dimensional mo…
Crawling in a fluid
Alexander Farutin, Jocelyn Etienne, Chaouqi Misbah +1
There is increasing evidence that mammalian cells not only crawl on substrates but can also swim in fluids. To elucidate the mechanisms of the onset of motility of cells in suspens…
Theory of mechano-chemical patterning in biphasic biological tissues
P. Recho, A. Hallou, E. Hannezo
The formation of self-organized patterns is key to the morphogenesis of multicellular organisms, although a comprehensive theory of biological pattern formation is still lacking. H…
On the quasi-static effective behaviour of poroelastic media containing elastic inclusions
Pascale Royer, Pierre Recho, Claude Verdier
The aim of the present study is to derive the effective quasi-static behaviour of a composite medium, made of a poroelastic matrix containing elastic impervious inclusions. For thi…
Colliding cells: when active segments behave as active particles
Pierre Recho, Thibaut Putelat, Lev Truskinovsky
Quantifying the outcomes of cells collisions is a crucial step in building the foundations of a kinetic theory of living matter. Here, we develop a mechanical theory of such collis…
Mechanical stress as a regulator of cell motility
Thibaut Putelat, Pierre Recho, Lev Truskinovsky
The motility of a cell can be triggered or inhibited not only by an applied force but also by a mechanically neutral force couple. This type of loading, represented by an applied s…
One-dimensional collective migration of a proliferating cell monolayer
Pierre Recho, Jonas Ranft, Philippe Marcq
The importance of collective cellular migration during embryogenesis and tissue repair asks for a sound understanding of underlying principles and mechanisms. Here, we address rece…
Growth, collapse, and stalling in a mechanical model for neurite motility
Pierre Recho, Antoine Jérusalem, Alain Goriely
Neurites, the long cellular protrusions that form the routes of the neuronal network are capable to actively extend during early morphogenesis or to regenerate after trauma. To per…
Pseudo energy wells in active systems
Raman Sheshka, Pierre Recho, Lev Truskinovsky
Active stabilization in systems with zero or negative stiffness is an essential element of a wide variety of biological processes. We study a prototypical example of this phenomeno…
Maximum velocity of self-propulsion for an active segment
Pierre Recho, Lev Truskinovsky
The motor part of a crawling eukaryotic cell can be represented schematically as an active continuum layer. The main active processes in this layer are protrusion, originating from…
Mechanics of motility initiation and motility arrest in crawling cells
Pierre Recho, Thibaut Putelat, Lev Truskinovsky
Motility initiation in crawling cells requires transformation of a symmetric state into a polarized state. In contrast, motility arrest is associated with re-symmetrization of the…
An asymmetry between pushing and pulling for crawling cells
Pierre Recho, Lev Truskinovsky
Eukaryotic cells possess motility mechanisms allowing them not only to self-propel but also to exert forces on obstacles (to push) and to carry cargoes (to pull). To study the inhe…
Mechanotaxis and cell motility
Pierre Recho, Thibault Putelat, Lev Truskinovsky
We propose a mechanism of cell motility which is based on contraction and does not require protrusion. The contraction driven translocation of a cell is due to internal flow of the…