One-dimensional collective migration of a proliferating cell monolayer

Abstract

The importance of collective cellular migration during embryogenesis and tissue repair asks for a sound understanding of underlying principles and mechanisms. Here, we address recent in vitro experiments on cell monolayers which show that the advancement of the leading edge relies on cell proliferation and protrusive activity at the tissue margin. Within a simple viscoelastic mechanical model amenable to detailed analysis, we identify a key parameter responsible for tissue expansion, and we determine the dependence of the monolayer velocity as a function of measurable rheological parameters. Our results allow us to discuss the effects of pharmacological perturbations on the observed tissue dynamics.

12 pages, 5 figures

References in corpus (2)

• Border forces and friction control epithelial closure dynamics
• Optimality of contraction-driven crawling

Cited by in corpus (8)

• Physical Models of Collective Cell Migration
• Active Fingering Instability in Tissue Spreading
• Active dynamics of tissue shear flow
• Role of Substrate Stiffness in Tissue Spreading: Wetting Transition and Tissue Durotaxis
• Stability and roughness of interfaces in mechanically-regulated tissues
• Emergence of epithelial cell density waves
• Cell growth, division and death in cohesive tissues: a thermodynamic approach
• Collective durotaxis of cohesive cell clusters on a stiffness gradient