794 citations · 1.8k across the 40 of their papers we have counts for
5 papers · 1 filter
Tensor clustering with algebraic constraints gives interpretable groups of crosstalk mechanisms in breast cancer
Anna Seigal, Mariano Beguerisse-Díaz, Birgit Schoeberl +2
We introduce a tensor-based clustering method to extract sparse, low-dimensional structure from high-dimensional, multi-indexed datasets. This framework is designed to enable detec…
The Topological "Shape" of Brexit
Bernadette J. Stolz, Heather A. Harrington, Mason A. Porter
Persistent homology is a method from computational algebraic topology that can be used to study the "shape" of data. We illustrate two filtrations --- the weight rank clique filtra…
The Role of the Hes1 Crosstalk Hub in Notch-Wnt Interactions of the Intestinal Crypt
Sophie K. Kay, Heather A. Harrington, Sarah Shepherd +5
The Notch pathway plays a vital role in determining whether cells in the intestinal epithelium adopt a secretory or an absorptive phenotype. Cell fate specification is coordinated…
The geometry of sloppiness
Emilie Dufresne, Heather A. Harrington, Dhruva V. Raman
The use of mathematical models in the sciences often involves the estimation of unknown parameter values from data. Sloppiness provides information about the uncertainty of this ta…
Decomposing the parameter space of biological networks via a numerical discriminant approach
Heather A. Harrington, Dhagash Mehta, Helen M. Byrne +1
Many systems in biology, physics and engineering can be described by systems of ordinary differential equation containing many parameters. When studying the dynamic behavior of the…