95 citations · 214 across the 11 of their papers we have counts for
11 papers
Optimal intercellular competition in senescence and cancer
Thomas C. T. Michaels, L. Mahadevan
Effective multicellularity requires both cooperation and competition between constituent cells. Cooperation involves sacrificing individual fitness in favor of that of the communit…
Hamiltonian Dynamics of Saturated Elongation in Amyloid Fiber Formation
Liu Hong, Xizhou Liu, Thomas C. T. Michaels +1
Elongation is a fundament process in amyloid fiber growth, which is normally characterized by a linear relationship between the fiber elongation rate and the monomer concentration.…
Deformable and robust core-shell protein microcapsules templated by liquid-liquid phase separated microdroplets
Yufan Xu, Yi Shen, Thomas C. T. Michaels +13
Microcapsules are a key class of microscale materials with applications in areas ranging from personal care to biomedicine, and with increasing potential to act as extracellular ma…
Mechanism, scaling and rates of protein aggregation from in vivo measurements
Georg Meisl, Alexander J Dear, Thomas CT Michaels +1
The formation and proliferation of protein aggregates play a central role in a number of devastating neuro-degenerative diseases. Many experimental studies indicate that the abilit…
Optimal control of aging in complex networks
Eric D. Sun, Thomas C. T. Michaels, L. Mahadevan
Many complex systems experience damage accumulation which leads to aging, manifest as an increasing probability of system collapse with time. This naturally raises the question of…
Geometric localization in supported elastic struts
Thomas C. T. Michaels, Remy Kusters, Alexander J. Dear +3
Localized deformation patterns are a common motif in morphogenesis and are increasingly finding widespread applications in materials science, for instance as memory devices. Here w…