339 citations · 525 across the 7 of their papers we have counts for
7 papers
A reproducible effect size is more useful than an irreproducible hypothesis test to analyze high throughput sequencing datasets
Andrew D. Fernandes, Michael T. H. Q. Vu, Lisa-Monique Edward +2
Motivation: P values derived from the null hypothesis significance testing framework are strongly affected by sample size, and are known to be irreproducible in underpowered studie…
Finding the centre: corrections for asymmetry in high-throughput sequencing datasets
Jia R. Wu, Jean M. Macklaim, Briana L. Genge +1
High throughput sequencing is a technology that allows for the generation of millions of reads of genomic data regarding a study of interest, and data from high throughput sequenci…
A multi-platform metabolomics approach identifies novel biomarkers associated with bacterial diversity in the human vagina
Amy McMillan, Stephen Rulisa, Mark Sumarah +5
Bacterial vaginosis (BV) increases transmission of HIV, enhances the risk of preterm labour, and its associated malodour impacts the quality of life for many women. Clinical diagno…
Control of catalytic efficiency by a co-evolving network of catalytic and non-catalytic residues
Thomas A. McMurrough, Russel J. Dickson, Stephanie M. F. Thibert +2
The active sites of enzymes consist of residues necessary for catalysis, and structurally important non-catalytic residues that together maintain the architecture and function of t…
XORRO: Rapid Paired-End Read Overlapper
Russell J. Dickson, Gregory B. Gloor
Background: Computational analysis of next-generation sequencing data is outpaced by data generation in many cases. In one such case, paired-end reads can be produced from the Illu…
The MIp Toolset: an efficient algorithm for calculating Mutual Information in protein alignments
Russell J. Dickson, Gregory B. Gloor
Background: Coevolution within a protein family is often predicted using statistics that measure the degree of covariation between positions in the protein sequence. Mutual Informa…
Microbiome profiling by Illumina sequencing of combinatorial sequence-tagged PCR products
Gregory B. Gloor, Ruben Hummelen, Jean M. Macklaim +4
We developed a low-cost, high-throughput microbiome profiling method that uses combinatorial sequence tags attached to PCR primers that amplify the rRNA V6 region. Amplified PCR pr…