4 papers · 1 filter
A folding inhibitor of the HIV-1 Protease
R. A. Broglia, D. Provasi, F. Vasile +3
Being the HIV-1 Protease (HIV-1-PR) an essential enzyme in the viral life cycle, its inhibition can control AIDS. The folding of single domain proteins, like each of the monomers f…
Design of amino acid sequences to fold into C_alpha-model proteins
A. Amatori, G. Tiana, L. Sutto +3
In order to extend the results obtained with minimal lattice models to more realistic systems, we study a model where proteins are described as a chain of 20 kinds of structureless…
Design of a folding inhibitor of the HIV-1 Protease
R. A. Broglia, G. Tiana, D. Provasi +4
Being HIV-1-PR an essential enzyme in the viral life cycle, its inhibition can control AIDS. Because the folding of single domain proteins, like HIV-1-PR is controlled by local ele…
Deriving amino acid contact potentials from their frequencies of occurence in proteins: a lattice model study
G. Tiana, M. Colombo, D. Provasi +1
The possibility of deriving the contact potentials between amino acids from their frequencies of occurence in proteins is discussed in evolutionary terms. This approach allows the…