3 papers
q-bio.BM2005
A folding inhibitor of the HIV-1 Protease
R. A. Broglia, D. Provasi, F. Vasile +3
Being the HIV-1 Protease (HIV-1-PR) an essential enzyme in the viral life cycle, its inhibition can control AIDS. The folding of single domain proteins, like each of the monomers f…
q-bio.BM2004
Design of a folding inhibitor of the HIV-1 Protease
R. A. Broglia, G. Tiana, D. Provasi +4
Being HIV-1-PR an essential enzyme in the viral life cycle, its inhibition can control AIDS. Because the folding of single domain proteins, like HIV-1-PR is controlled by local ele…
cond-mat.soft1999
Hiking in the energy landscape in sequence space: a bumpy road to good folders
G. Tiana, R. A. Broglia, E. I. Shakhnovich
With the help of a simple 20 letters, lattice model of heteropolymers, we investigate the energy landscape in the space of designed good-folder sequences. Low-energy sequences form…