1 citations · 1 across the 2 of their papers we have counts for
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Clonal Interference, Multiple Mutations, and Adaptation in Large Asexual Populations
Craig A. Fogle, James L. Nagle, Michael M. Desai
Two important problems affect the ability of asexual populations to accumulate beneficial mutations, and hence to adapt. First, clonal interference causes some beneficial mutations…
Detecting Directional Selection from the Polymorphism Frequency Spectrum
Michael M Desai, Joshua B. Plotkin
The distribution of genetic polymorphisms in a population contains information about the mutation rate and the strength of natural selection at a locus. Here, we show that the Pois…
Beneficial mutation-selection balance and the effect of linkage on positive selection
Michael M. Desai, Daniel S. Fisher
When beneficial mutations are rare, they accumulate by a series of selective sweeps. But when they are common, many beneficial mutations will occur before any can fix, so there wil…
A Quasispecies on a Moving Oasis
Michael M. Desai, David R. Nelson
A population evolving in an inhomogeneous environment will adapt differently to different regions. We study the conditions under which such a population can maintain adaptations to…