92 citations · 298 across the 9 of their papers we have counts for
9 papers
Fluctuations in protein aggregation: Design of preclinical screening for early diagnosis of neurodegenerative disease
Giulio Costantini, Zoe Budrikis, Alessandro Taloni +3
Autocatalytic fibril nucleation has recently been proposed to be a determining factor for the spread of neurodegenerative diseases, but the same process could also be exploited to…
Role of the Number of Microtubules in Chromosome Segregation during Cell Division
Zsolt Bertalan, Zoe Budrikis, Caterina A. M. La Porta +1
Faithful segregation of genetic material during cell division requires alignment of chromosomes between two spindle poles and attachment of their kinetochores to each of the poles.…
Overshoot during phenotypic switching of cancer cell populations
Alessandro L. Sellerio, Emilio Ciusani, Noa Bossel Ben-Moshe +7
The dynamics of tumor cell populations is hotly debated: do populations derive hierarchically from a subpopulation of cancer stem cells (CSCs), or are stochastic transitions that m…
Navigation strategies of motor proteins on decorated tracks
Zsolt Bertalan, Zoe Budrikis, Caterina A. M. La Porta +1
Motor proteins display widely different stepping patterns as they move on microtubule tracks, from the deterministic linear or helical motion performed by the protein kinesin to th…
Conformational mechanism for the stability of microtubule-kinetochore attachments
Zsolt Bertalan, Caterina A. M. La Porta, Helder Maiato +1
Regulating the stability of microtubule(MT)-kinetochore attachments is fundamental to avoiding mitotic errors and ensure proper chromosome segregation during cell division. While b…
Mechanical Properties of Growing Melanocytic Nevi and the Progression to Melanoma
Alessandro Taloni, Alexander A. Alemi, Emilio Ciusani +3
Melanocytic nevi are benign proliferations that sometimes turn into malignant melanoma in a way that is still unclear from the biochemical and genetic point of view. Diagnostic and…
Protein accumulation in the endoplasmic reticulum as a non-equilibrium phase transition
Z. Budrikis, G. Costantini, C. A. La Porta +1
Several neurological disorders are associated with the aggregation of aberrant proteins, often localized in intracellular organelles such as the endoplasmic reticulum. Here we stud…
Do cancer cells undergo phenotypic switching? The case for imperfect cancer stem cell markers
C. A. M. La Porta, S Zapperi
The identification of cancer stem cells in vivo and in vitro relies on specific surface markers that should allow to sort cancer cells in phenotypically distinct subpopulations. Ex…
Senescent Cells in Growing Tumors: Population Dynamics and Cancer Stem Cells
Caterina A. M. La Porta, Stefano Zapperi, James P. Sethna
Tumors are defined by their intense proliferation, but sometimes cancer cells turn senescent and stop replicating. In the stochastic cancer model in which all cells are tumorigenic…