410 citations · 485 across the 4 of their papers we have counts for
4 papers
Robustness of synthetic oscillators in growing and dividing cells
Joris Paijmans, David K Lubensky, Pieter Rein ten Wolde
Synthetic biology sets out to implement new functions in cells, and to develop a deeper understanding of biological design principles. In 2000, Elowitz and Leibler showed that by r…
Fundamental costs in the production and destruction of persistent polymer copies
Thomas E. Ouldridge, Pieter Rein ten Wolde
Living cells use readout molecules to record the state of receptor proteins, similar to measurements or copies in typical computational devices. But is this analogy rigorous? Can c…
The robustness of proofreading to crowding-induced pseudo-processivity in the MAPK pathway
Thomas E. Ouldridge, Pieter Rein ten Wolde
Double phosphorylation of protein kinases is a common feature of signalling cascades. This motif may reduce cross-talk between signalling pathways, as the second phosphorylation si…
Forward Flux Sampling for rare event simulations
Rosalind J. Allen, Chantal Valeriani, Pieter Rein ten Wolde
Rare events are ubiquitous in many different fields, yet they are notoriously difficult to simulate because few, if any, events are observed in a conventiona l simulation run. Over…