activity
20072020
most citedAccumulation of driver and passenger mutations during tumor progression

867 citations · 1.9k across the 5 of their papers we have counts for

collaborators

5 papers

q-bio.TO2020★ 34 cited

Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection

Allison Koenecke, Michael Powell, Ruoxuan Xiong +22

In severe viral pneumonia, including Coronavirus disease 2019 (COVID-19), the viral replication phase is often followed by hyperinflammation, which can lead to acute respiratory di…

q-bio.PE2015★ 537 cited

Spatial model predicts dispersal and cell turnover cause reduced intra-tumor heterogeneity

Bartlomiej Waclaw, Ivana Bozic, Meredith E. Pittman +3

Most cancers in humans are large, measuring centimeters in diameter, composed of many billions of cells. An equivalent mass of normal cells would be highly heterogeneous as a resul…

stat.AP2015★ 18 cited

Musings on the theory that variation in cancer risk among tissues can be explained by the number of divisions of normal stem cells

Cristian Tomasetti, Bert Vogelstein

This manuscript has been written to address questions related to our recent publication (Science 347:78-81, 2015). We appreciate the many reactions to this paper that have been com…

q-bio.PE2009★ 867 cited

Accumulation of driver and passenger mutations during tumor progression

Ivana Bozic, Tibor Antal, Hisashi Ohtsuki +7

Major efforts to sequence cancer genomes are now occurring throughout the world. Though the emerging data from these studies are illuminating, their reconciliation with epidemiolog…

q-bio.PE2007★ 417 cited

Genetic progression and the waiting time to cancer

Niko Beerenwinkel, Tibor Antal, David Dingli +5

Cancer results from genetic alterations that disturb the normal cooperative behavior of cells. Recent high-throughput genomic studies of cancer cells have shown that the mutational…