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stat.ME2026
Testing for subgroup treatment effect consistency in the Cox model
Lukas Koletzko, Holger Dette, Björn Bornkamp +3
An overall treatment effect in a clinical trial may inadequately represent particular patient subgroups, creating uncertainty about whether a population-level efficacy conclusion c…
stat.ME2025
Randomization-based Inference for MCP-Mod
Lukas Pin, Oleksandr Sverdlov, Frank Bretz +1
Dose selection is critical in pharmaceutical drug development, as it directly impacts therapeutic efficacy and patient safety of a drug. The Generalized Multiple Comparison Procedu…
stat.ME2024
Futility analyses for the MCP-Mod methodology based on longitudinal models
Björn Bornkamp, Jie Zhou, Dong Xi +1
This article discusses futility analyses for the MCP-Mod methodology. Formulas are derived for calculating predictive and conditional power for MCP-Mod, which also cover the case w…