3 papers
stat.ME2026
Testing for subgroup treatment effect consistency in the Cox model
Lukas Koletzko, Holger Dette, Björn Bornkamp +3
An overall treatment effect in a clinical trial may inadequately represent particular patient subgroups, creating uncertainty about whether a population-level efficacy conclusion c…
stat.ME2025
Randomization-based Inference for MCP-Mod
Lukas Pin, Oleksandr Sverdlov, Frank Bretz +1
Dose selection is critical in pharmaceutical drug development, as it directly impacts therapeutic efficacy and patient safety of a drug. The Generalized Multiple Comparison Procedu…
stat.AP2025
WATCH: A Workflow to Assess Treatment Effect Heterogeneity in Drug Development for Clinical Trial Sponsors
Konstantinos Sechidis, Sophie Sun, Yao Chen +8
This paper proposes a Workflow for Assessing Treatment effeCt Heterogeneity (WATCH) in clinical drug development targeted at clinical trial sponsors. WATCH is designed to address t…