68 citations · 120 across the 6 of their papers we have counts for
7 papers
New views of old proteins: clarifying the enigmatic proteome
Participants in a NIH Workshop on Functional, Integrative Proteomics, : +20
All human diseases involve proteins, yet our current tools to characterize and quantify them are limited. To better elucidate proteins across space, time, and molecular composition…
Trace Reconstruction Problems in Computational Biology
Vinnu Bhardwaj, Pavel A. Pevzner, Cyrus Rashtchian +1
The problem of reconstructing a string from its error-prone copies, the trace reconstruction problem, was introduced by Vladimir Levenshtein two decades ago. While there has been c…
De novo inference of diversity genes and analysis of non-canonical V(DD)J recombination in immunoglobulins
Yana Safonova, Pavel A. Pevzner
The V(D)J recombination forms the immunoglobulin genes by joining the variable (V), diversity (D), and joining (J) germline genes. Since variations in germline genes have been link…
Reconstructing antibody repertoires from error-prone immunosequencing datasets
Alexander Shlemov, Sergey Bankevich, Andrey Bzikadze +3
Transforming error-prone immunosequencing datasets into antibody repertoires is a fundamental problem in immunogenomics, and a prerequisite for studies of immune responses. Althoug…
metaSPAdes: a new versatile de novo metagenomics assembler
Sergey Nurk, Dmitry Meleshko, Anton Korobeynikov +1
While metagenomics has emerged as a technology of choice for analyzing bacterial populations, assembly of metagenomic data remains difficult thus stifling biological discoveries. m…
Single-Molecule Protein Identification by Sub-Nanopore Sensors
Mikhail Kolmogorov, Eamonn Kennedy, Zhuxin Dong +2
Recent advances in top-down mass spectrometry enabled identification of intact proteins, but this technology still faces challenges. For example, top-down mass spectrometry suffers…
Limited Lifespan of Fragile Regions in Mammalian Evolution
Max A. Alekseyev, Pavel A. Pevzner
An important question in genome evolution is whether there exist fragile regions (rearrangement hotspots) where chromosomal rearrangements are happening over and over again. Althou…