10 citations · 16 across the 10 of their papers we have counts for
5 papers · 1 filter
Heterogeneity-aware integrative regression for ancestry-specific association studies
Aaron J. Molstad, Yanwei Cai, Alexander P. Reiner +3
Ancestry-specific proteome-wide association studies (PWAS) based on genetically predicted protein expression can reveal complex disease etiology specific to certain ancestral group…
A covariance-enhanced approach to multi-tissue joint eQTL mapping with application to transcriptome-wide association studies
Aaron J. Molstad, Wei Sun, Li Hsu
Transcriptome-wide association studies based on genetically predicted gene expression have the potential to identify novel regions associated with various complex traits. It has be…
Joint estimation of genetic and parent-of-origin effects using RNA-seq data from human
Vasyl Zhabotynsky, Wei Sun, Kaoru Inoue +2
RNA sequencing allows one to study allelic imbalance of gene expression, which may be due to genetic factors or genomic imprinting. It is desirable to model both genetic and parent…
IsoDOT Detects Differential RNA-isoform Expression/Usage with respect to a Categorical or Continuous Covariate with High Sensitivity and Specificity
Wei Sun, Yufeng Liu, James J. Crowley +14
We have developed a statistical method named IsoDOT to assess differential isoform expression (DIE) and differential isoform usage (DIU) using RNA-seq data. Here isoform usage refe…
A geometric interpretation of the permutation -value and its application in eQTL studies
Wei Sun, Fred A. Wright
Permutation -values have been widely used to assess the significance of linkage or association in genetic studies. However, the application in large-scale studies is hindered by…