Cellular tango: How extracellular matrix adhesion choreographs Rac-Rho signaling and cell movement

Elisabeth G. Rens, Leah Edelstein-Keshet

The small GTPases Rac and Rho are known to regulate eukaryotic cell shape, promoting front protrusion (Rac) or rear retraction (Rho) of the cell edge. Such cell deformation changes…