97 citations · 98 across the 3 of their papers we have counts for
5 papers
Bridging from single to collective cell migration: A review of models and links to experiments
Andreas Buttenschön, Leah Edelstein-Keshet
Mathematical and computational models can assist in gaining an understanding of cell behavior at many levels of organization. Here, we review models in the literature that focus on…
Cell size, mechanical tension, and GTPase signaling in the Single Cell
Andreas Buttenschön, Yue Liu, Leah Edelstein-Keshet
Cell polarization requires redistribution of specific proteins to the nascent front and back of a eukarytotic cell. Among these proteins are Rac and Rho, members of the small GTPas…
A coupled bulk-surface model for cell polarisation
Davide Cusseddu, Leah Edelstein-Keshet, John A. Mackenzie +2
Several cellular activities, such as directed cell migration, are coordinated by an intricate network of biochemical reactions which lead to a polarised state of the cell, in which…
Asymptotic and bifurcation analysis of wave-pinning in a reaction-diffusion model for cell polarization
Yoichiro Mori, Alexandra Jilkine, Leah Edelstein-Keshet
We describe and analyze a bistable reaction-diffusion (RD) model for two interconverting chemical species that exhibits a phenomenon of wave-pinning: a wave of activation of one of…
A computational model of cell polarization and motility coupling mechanics and biochemistry
Ben Vanderlei, James J. Feng, Leah Edelstein-Keshet
The motion of a eukaryotic cell presents a variety of interesting and challenging problems from both a modeling and a computational perspective. The processes span many spatial sca…