182 citations · 274 across the 6 of their papers we have counts for
3 papers · 1 filter
Random Norming Aids Analysis of Non-linear Regression Models with Sequential Informative Dose Selection
Zhantao Lin, Nancy Flournoy, William F. Rosenberger
A two-stage adaptive optimal design is an attractive option for increasing the efficiency of clinical trials. In these designs, based on interim data, the locally optimal dose is c…
Nonparametric covariate-adjusted response-adaptive design based on a functional urn model
Giacomo Aletti, Andrea Ghiglietti, William F. Rosenberger
In this paper we propose a general class of covariate-adjusted response-adaptive (CARA) designs based on a new functional urn model. We prove strong consistency concerning the func…
Handling Covariates in the Design of Clinical Trials
William F. Rosenberger, Oleksandr Sverdlov
There has been a split in the statistics community about the need for taking covariates into account in the design phase of a clinical trial. There are many advocates of using stra…