182 citations · 274 across the 6 of their papers we have counts for
7 papers
Random Norming Aids Analysis of Non-linear Regression Models with Sequential Informative Dose Selection
Zhantao Lin, Nancy Flournoy, William F. Rosenberger
A two-stage adaptive optimal design is an attractive option for increasing the efficiency of clinical trials. In these designs, based on interim data, the locally optimal dose is c…
Nonparametric covariate-adjusted response-adaptive design based on a functional urn model
Giacomo Aletti, Andrea Ghiglietti, William F. Rosenberger
In this paper we propose a general class of covariate-adjusted response-adaptive (CARA) designs based on a new functional urn model. We prove strong consistency concerning the func…
A Conversation with Nancy Flournoy
William F. Rosenberger
Nancy Flournoy was born in Long Beach, California, on May 4, 1947. After graduating from Polytechnic School in Pasadena in 1965, she earned a B.S. (1969) and M.S. (1971) in biostat…
Central limit Theorem for an Adaptive Randomly Reinforced Urn Model
Andrea Ghiglietti, Anand N. Vidyashankar, William F. Rosenberger
The generalized Pòlya urn (GPU) models and their variants have been investigated in several disciplines. However, typical assumptions made with respect to the GPU do not include ur…
Sequential monitoring with conditional randomization tests
Victoria Plamadeala, William F. Rosenberger
Sequential monitoring in clinical trials is often employed to allow for early stopping and other interim decisions, while maintaining the type I error rate. However, sequential mon…
Handling Covariates in the Design of Clinical Trials
William F. Rosenberger, Oleksandr Sverdlov
There has been a split in the statistics community about the need for taking covariates into account in the design phase of a clinical trial. There are many advocates of using stra…