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q-bio.MN2020
Exact derivation and practical application of a hybrid stochastic simulation algorithm for large gene regulatory networks
Jaroslav Albert
We present a highly efficient and accurate hybrid stochastic simulation algorithm (HSSA) for the purpose of simulating a subset of biochemical reactions of large gene regulatory ne…
q-bio.MN2020
Dimensionality reduction via path integration for computing mRNA distributions
Jaroslav Albert
Inherent stochasticity in gene expression leads to distributions of mRNA copy numbers in a population of identical cells. These distributions are determined primarily by the multit…