3 papers
q-bio.MN2020
Exact derivation and practical application of a hybrid stochastic simulation algorithm for large gene regulatory networks
Jaroslav Albert
We present a highly efficient and accurate hybrid stochastic simulation algorithm (HSSA) for the purpose of simulating a subset of biochemical reactions of large gene regulatory ne…
q-bio.MN2020
Dimensionality reduction via path integration for computing mRNA distributions
Jaroslav Albert
Inherent stochasticity in gene expression leads to distributions of mRNA copy numbers in a population of identical cells. These distributions are determined primarily by the multit…
q-bio.MN2011
Dynamic modeling of gene expression in prokaryotes: application to glucose-lactose diauxie in Escherichia coli
Jaroslav Albert, Marianne Rooman
Coexpression of genes or, more generally, similarity in the expression profiles poses an unsurmountable obstacle to inferring the gene regulatory network (GRN) based solely on data…