197 citations · 492 across the 14 of their papers we have counts for
14 papers
Kinetics of seeded protein aggregation: theory and application
Alexander J. Dear, Georg Meisl, Jing Hu +2
``Seeding'' is the addition of preformed fibrils to a solution of monomeric protein to accelerate its aggregation into new fibrils. It is a versatile and widely-used tool for scien…
Competing addition processes give distinct growth regimes in the assembly of 1D filaments
Sk Ashif Akram, Tyler Brown, Stephen Whitelam +3
We present a model to describe the concentration-dependent growth of protein filaments. Our model contains two states, a low entropy/high affinity ordered state and a high entropy/…
Hamiltonian Dynamics of Saturated Elongation in Amyloid Fiber Formation
Liu Hong, Xizhou Liu, Thomas C. T. Michaels +1
Elongation is a fundament process in amyloid fiber growth, which is normally characterized by a linear relationship between the fiber elongation rate and the monomer concentration.…
The role of clearance mechanisms in the kinetics of toxic protein aggregates involved in neurodegenerative diseases
Travis B. Thompson, Georg Meisl, Tuomas Knowles +1
Protein aggregates in the brain play a central role in cognitive decline and structural damage associated with neurodegenerative diseases. For instance, in Alzheimer's disease the…
Deformable and robust core-shell protein microcapsules templated by liquid-liquid phase separated microdroplets
Yufan Xu, Yi Shen, Thomas C. T. Michaels +13
Microcapsules are a key class of microscale materials with applications in areas ranging from personal care to biomedicine, and with increasing potential to act as extracellular ma…
Mechanism, scaling and rates of protein aggregation from in vivo measurements
Georg Meisl, Alexander J Dear, Thomas CT Michaels +1
The formation and proliferation of protein aggregates play a central role in a number of devastating neuro-degenerative diseases. Many experimental studies indicate that the abilit…
Reaction rate theory for supramolecular kinetics: application to protein aggregation
Thomas C. T. Michaels, Lucie X. Liu, Samo Curk +3
Probing the reaction mechanisms of supramolecular processes in soft- and biological matter, such as protein aggregation, is inherently challenging. These processes emerge from the…
Kinetics of spontaneous filament nucleation via oligomers: insights from theory and simulation
Anđela Šarić, Thomas C. T. Michaels, Alessio Zaccone +2
Nucleation processes are at the heart of a large number of phenomena, from cloud formation to protein crystallization. A recently emerging area where nucleation is highly relevant…
Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers
Patrick Varilly, Adam P. Willard, Julius B. Kirkegaard +2
Aggregation of amphiphiles through the action of hydrophobic interactions is a common feature in soft condensed matter systems and is of particular importance in the context of bio…
A general reaction network unifies the aggregation behaviour of the A42 peptide and its variants
Georg Meisl, Xiaoting Yang, Christopher M. Dobson +2
The amyloid peptide (A42), whose aggregation is associated with Alzheimer's disease, is an amphiphatic peptide with a high propensity to self-assemble. A42 has a net nega…
Consistent treatment of hydrophobicity in protein lattice models accounts for cold denaturation
Erik van Dijk, Patrick Varilly, Tuomas Knowles +2
The hydrophobic effect stabilizes the native structure of proteins by minimizing the unfavourable interactions between hydrophobic residues and water through the formation of a hyd…
Oligomers of heat-shock proteins: Structures that don't imply function
William M. Jacobs, Tuomas P. J. Knowles, Daan Frenkel
Most proteins must remain soluble in the cytosol in order to perform their biological functions. To protect against undesired protein aggregation, living cells maintain a populatio…
Crucial role of non-specific interactions in amyloid nucleation
Anđela Šarić, Yassmine C. Chebaro, Tuomas P. J. Knowles +1
Protein oligomers have been implicated as toxic agents in a wide range of amyloid-related diseases. Yet it has remained unsolved whether the oligomers are a necessary step in the f…
Nucleated polymerisation in the presence of pre-formed seed filaments
Samuel I. A. Cohen, Michele Vendruscolo, Christopher M. Dobson +1
We revisit the classical problem of nucleated polymerisation and derive a range of exact results describing polymerisation in systems intermediate between the well-known limiting c…